A-1155463 Dihydrochloride
A-1155463 Dihydrochloride, a highly potent and selective BCL-XL inhibitor, shows picomolar binding affinity to BCL-XL, and >1000-fold weaker binding to BCL-2 and related proteins BCL-W(Ki=19 nM) and MCL-1(Ki>440 nM).
| Trivial name | N/A |
| Catalog Number | S7800 |
| Molecular Formula | C35H34Cl2FN5O4S2 |
| CAS# | 1235034-55-5(free base) |
| Inchi | InChI=1S/C35H32FN5O4S2/c1-40(2)17-6-8-22-14-15-28(26(36)20-22)45-19-7-13-30-31(33(43)44)38-35(47-30)41-18-16-23-9-5-10-24(25(23)21-41)32(42)39-34-37-27-11-3-4-12-29(27)46-34/h3-5,9-12,14-15,20H,7,13,1 6-19,21H2,1-2H3,(H,43,44)(H,37,39,42) |
| Inchi Key | SOYCFODXNRVBTI-UHFFFAOYSA-N |
| SMILES | CN(C)CC#CC1=CC(=C(C=C1)OCCCC2=C(N=C(S2)N3CCC4=C(C3)C(=CC=C4)C(=O)NC5=NC6=CC=CC=C6S5)C(=O)O)F |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/a-1155463.html |
| Additional Information | https://file.selleck.cn/downloads/struct/a-1155463-chemical-structure-s7800.gif |