Savolitinib (AZD6094)

Savolitinib (Volitinib, AZD6094, HMPL-504) is a novel, potent, and selective MET inhibitor currently in clinical development in various indications, including PRCC. The IC50 values of this compound for c-Met and p-Met are 5 nM and 3 nM, respectively. It shows exquisite selectivity for c-Met over 274 kinase.

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Trivial name	HMPL-504, Volitinib
Catalog Number	S7674
Molecular Formula	C17H15N9
CAS#	1313725-88-0
Inchi	InChI=1S/C17H15N9/c1-11(12-3-4-15-18-5-6-25(15)10-12)26-17-16(22-23-26)19-8-14(21-17)13-7-20-24(2)9-13/h3-11H,1-2H3/t11-/m0/s1
Inchi Key	XYDNMOZJKOGZLS-NSHDSACASA-N
SMILES	CC(C1=CN2C=CN=C2C=C1)N3C4=NC(=CN=C4N=N3)C5=CN(N=C5)C
Size	1g
Supplier Page	http://www.selleckchem.com/products/hmpl-504-azd6094-volitinib.html
Additional Information	https://file.selleck.cn/downloads/struct/hmpl-504-azd6094-volitinib-chemical-structure-s7674.gif