Picropodophyllin (PPP)

Picropodophyllin (PPP, AXL1717) is a IGF-1R inhibitor with IC50 of 1 nM. It displays selectivity for IGF-1R and does not coinhibit tyrosine phosphorylation the IR, or of a selected panel of receptors less related to IGF-IR(FGF-R, PDGF-R, OR EGF-R). Picropodophyllin (PPP) induces apoptosis with antineoplastic activity.

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Trivial name	AXL1717
Catalog Number	S7668
Molecular Formula	C22H22O8
CAS#	477-47-4
Inchi	InChI=1S/C22H22O8/c1-25-16-4-10(5-17(26-2)21(16)27-3)18-11-6-14-15(30-9-29-14)7-12(11)20(23)13-8-28-22(24)19(13)18/h4-7,13,18-20,23H,8-9H2,1-3H3/t13-,18+,19+,20-/m0/s1
Inchi Key	YJGVMLPVUAXIQN-HAEOHBJNSA-N
SMILES	COC1=CC(=CC(=C1OC)OC)C2C3C(COC3=O)C(C4=CC5=C(C=C24)OCO5)O
Size	10mM/1mL
Supplier Page	http://www.selleckchem.com/products/picropodophyllin-ppp.html
Additional Information	https://file.selleck.cn/downloads/struct/picropodophyllin-ppp-chemical-structure-s7668.gif