OTS964
OTS964 is a potent TOPK inhibitor with high affinity and selectivity and IC50 value is 28 nM. OTS964 is also a potent inhibitor of the cyclin-dependent kinase CDK11 with Kd of 40 nM. OTS964 treatment activates autophagy in glioma cells and induces apoptosis of human lung cancer cells in mouse xenografts.
| Trivial name | N/A |
| Catalog Number | S7648 |
| Molecular Formula | C23H24N2O2S.HCl |
| CAS# | 1338545-07-5 |
| Inchi | InChI=1S/C23H24N2O2S.2ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17-9-10-28-22(17)23(27)24-21(13)20;;/h5-11,14,26H,12H2,1-4H3,(H,24,27);2*1H/t14-;;/m0../s1 |
| Inchi Key | GLJFLFGVONZZCS-UTLKBRERSA-N |
| SMILES | CC1=CC(=C(C2=C1NC(=O)C3=C2C=CS3)C4=CC=C(C=C4)C(C)CN(C)C)O.Cl |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/ots964.html |
| Additional Information | https://file.selleck.cn/downloads/struct/ots964-chemical-structure-s7648.gif |