Vactosertib (TEW-7197)
Vactosertib (TEW-7197, EW-7197) is a highly potent, selective, and orally bioavailable TGF-β receptor ALK4/ALK5 inhibitor with IC50 of 13 nM and 11 nM, respectively. Phase 1.
Trivial name | EW-7197 |
Catalog Number | S7530 |
Molecular Formula | C22H18FN7 |
CAS# | 1352608-82-2 |
Inchi | InChI=1S/C22H18FN7/c1-14-5-4-8-18(27-14)22-21(15-9-10-20-25-13-26-30(20)12-15)28-19(29-22)11-24-17-7-3-2-6-16(17)23/h2-10,12-13,24H,11H2,1H3,(H,28,29) |
Inchi Key | FJCDSQATIJKQKA-UHFFFAOYSA-N |
SMILES | CC1=NC(=CC=C1)C2=C(N=C(N2)CNC3=CC=CC=C3F)C4=CN5C(=NC=N5)C=C4 |
Size | 100mg |
Supplier Page | http://www.selleckchem.com/products/ew-7197.html |
Additional Information | https://file.selleck.cn/downloads/struct/ew-7197-chemical-structure-s7530.gif |