KN-62
KN-62 is a potent and specific inhibitor of Ca2+/calmodulin-dependent protein kinase II (CaMKII) with Ki of 0.9 μM; also a non-competitive antagonist of the purinergic receptor P2RX7 (IC50 = 15 nM). It is selective for CaMKII relative to PKA, PKC and MLCK, but inhibits CaMKI and CaMKIV equally well, The Ki value of KN-62 for CaMK V is 0.8 μM.
| Trivial name | N/A |
| Catalog Number | S7422 |
| Molecular Formula | C38H35N5O6S2 |
| CAS# | 127191-97-3 |
| Inchi | InChI=1S/C38H35N5O6S2/c1-41(50(45,46)36-11-5-7-29-26-39-19-17-33(29)36)35(38(44)43-23-21-42(22-24-43)31-9-3-2-4-10-31)25-28-13-15-32(16-14-28)49-51(47,48)37-12-6-8-30-27-40-20-18-34(30)37/h2-20,26-27, 35H,21-25H2,1H3/t35-/m0/s1 |
| Inchi Key | RJVLFQBBRSMWHX-DHUJRADRSA-N |
| SMILES | CN(C(CC1=CC=C(C=C1)OS(=O)(=O)C2=CC=CC3=C2C=CN=C3)C(=O)N4CCN(CC4)C5=CC=CC=C5)S(=O)(=O)C6=CC=CC7=C6C=CN=C7 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/kn-62.html |
| Additional Information | https://file.selleck.cn/downloads/struct/KN-62-chemical-structure-s7422.gif |