Birabresib (OTX015)

Birabresib (OTX015, MK 8628) is a potent BET bromodomain inhibitor with EC50 ranging from 10 to 19 nM for BRD2, BRD3, and BRD4 in cell-free assays. Birabresib inhibits the expression of Nuclear receptor binding SET domain protein 3 (NSD3) target genes.

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Trivial name	MK 8628
Catalog Number	S7360
Molecular Formula	C25H22ClN5O2S
CAS#	202590-98-5
Inchi	InChI=1S/C25H22ClN5O2S/c1-13-14(2)34-25-22(13)23(16-4-6-17(26)7-5-16)28-20(24-30-29-15(3)31(24)25)12-21(33)27-18-8-10-19(32)11-9-18/h4-11,20,32H,12H2,1-3H3,(H,27,33)/t20-/m0/s1
Inchi Key	GNMUEVRJHCWKTO-FQEVSTJZSA-N
SMILES	CC1=C(SC2=C1C(=NC(C3=NN=C(N32)C)CC(=O)NC4=CC=C(C=C4)O)C5=CC=C(C=C5)Cl)C
Size	1g
Supplier Page	http://www.selleckchem.com/products/otx015.html
Additional Information	https://file.selleck.cn/downloads/struct/OTX015-chemical-structure-s7360.gif