Alvelestat (AZD9668)
Alvelestat (AZD9668, Avelestat) is an oral, highly selective inhibitor of neutrophil elastase (NE) with IC50 and Ki of 12 nM and 9.4 nM, at least 600-fold more selective over other serine proteases.
Phase 2.
| Trivial name | Avelestat |
| Catalog Number | S7218 |
| Molecular Formula | C25H22F3N5O4S |
| CAS# | 848141-11-7 |
| Inchi | InChI=1S/C24H20F3N5O4S/c1-31-21(8-9-30-31)15-10-20(22(33)29-12-17-6-7-19(13-28-17)37(2,35)36)23(34)32(14-15)18-5-3-4-16(11-18)24(25,26)27/h3-11,13-14H,12H2,1-2H3,(H,29,33) |
| Inchi Key | BSIRHPGCYXLICK-UHFFFAOYSA-N |
| SMILES | CC1=C(C=C(C(=O)N1C2=CC=CC(=C2)C(F)(F)F)C(=O)NCC3=NC=C(C=C3)S(=O)(=O)C)C4=CC=NN4C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/avelestat-azd9668.html |
| Additional Information | https://file.selleck.cn/downloads/struct/AZD9668-chemical-structure-s7218.gif |