BIO
BIO (GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3′-oxime, MLS 2052) is a specific inhibitor of GSK-3 with IC50 of 5 nM for GSK-3α/β in a cell-free assay, shows >16-fold selectivity over CDK5, also a pan-JAK inhibitor with IC50 of 30 nM for Tyk2. BIO induces apoptosis in human melanoma cells.
| Trivial name | GSK-3 Inhibitor IX, 6-bromoindirubin-3-oxime, 6-Bromoindirubin-3'-oxime, MLS 2052 |
| Catalog Number | S7198 |
| Molecular Formula | C16H10BrN3O2 |
| CAS# | 667463-62-9 |
| Inchi | InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18,22H,(H,19,21)/b15-13-,20-14+ |
| Inchi Key | DDLZLOKCJHBUHD-WAVHTBQISA-N |
| SMILES | C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC(=C4)Br)O)N=O |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/bio.html |
| Additional Information | https://file.selleck.cn/downloads/struct/BIO-chemical-structure-s7198.gif |