SC144
SC144 is the first-in-class orally active small-molecule gp130 inhibitor that induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes.
| Trivial name | N/A |
| Catalog Number | S7124 |
| Molecular Formula | C16H11FN6O |
| CAS# | 895158-95-9 |
| Inchi | InChI=1S/C16H11FN6O/c17-10-3-4-13-11(8-10)20-15(14-2-1-7-23(13)14)21-22-16(24)12-9-18-5-6-19-12/h1-9H,(H,20,21)(H,22,24) |
| Inchi Key | UEADAWQSJOWXBK-UHFFFAOYSA-N |
| SMILES | C1=CN2C3=C(C=C(C=C3)F)N=C(C2=C1)NNC(=O)C4=NC=CN=C4 |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/sc144.html |
| Additional Information | https://file.selleck.cn/downloads/struct/SC144-chemical-structure-s7124.gif |