PF-3758309
PF-03758309 (PF-03758309) is a potent, ATP-competitive, pyrrolopyrazole inhibitor of PAK4 with Kd of 2.7 nM. PF-3758309 is antiproliferative and induces apoptosis in a HCT116 tumor model.
| Trivial name | PF-03758309 |
| Catalog Number | S7094 |
| Molecular Formula | C25H30N8OS |
| CAS# | 898044-15-0 |
| Inchi | InChI=1S/C25H30N8OS/c1-15-26-18-11-12-35-20(18)23(27-15)29-22-17-13-33(25(2,3)21(17)30-31-22)24(34)28-19(14-32(4)5)16-9-7-6-8-10-16/h6-12,19H,13-14H2,1-5H3,(H,28,34)(H2,26,27,29,30,31)/t19-/m1/s1 |
| Inchi Key | AYCPARAPKDAOEN-LJQANCHMSA-N |
| SMILES | CC1=NC2=C(C(=N1)NC3=NNC4=C3CN(C4(C)C)C(=O)NC(CN(C)C)C5=CC=CC=C5)SC=C2 |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/pf-3758309.html |
| Additional Information | https://file.selleck.cn/downloads/struct/PF-3758309-chemical-structure-s7094.gif |