Tepotinib
Tepotinib is a potent and selective c-Met inhibitor with IC50 of 4 nM, >200-fold selective for c-Met than IRAK4, TrkA, Axl, IRAK1, and Mer. Tepotinib (EMD 1214063) induces autophagy. Phase 1.
| Trivial name | EMD 1214063, MSC2156119 |
| Catalog Number | S7067 |
| Molecular Formula | C29H28N6O2 |
| CAS# | 1100598-32-0 |
| Inchi | InChI=1S/C29H28N6O2/c1-34-12-10-21(11-13-34)20-37-26-17-31-29(32-18-26)25-7-3-5-23(15-25)19-35-28(36)9-8-27(33-35)24-6-2-4-22(14-24)16-30/h2-9,14-15,17-18,21H,10-13,19-20H2,1H3 |
| Inchi Key | AHYMHWXQRWRBKT-UHFFFAOYSA-N |
| SMILES | CN1CCC(CC1)COC2=CN=C(N=C2)C3=CC=CC(=C3)CN4C(=O)C=CC(=N4)C5=CC=CC(=C5)C#N |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/emd-1214063.html |
| Additional Information | https://file.selleck.cn/downloads/struct/EMD-1214063-chemical-structure-s7067.gif |