Duvelisib (IPI-145)
Duvelisib (IPI-145, INK1197) is a novel and selective PI3K δ/γ inhibitor with Ki and IC50 of 23 pM/243 pM and 1 nM/50 nM in cell-free assays, highly selective for PI3K δ/γ than other protein kinases. Phase 3.
Trivial name | INK1197 |
Catalog Number | S7028 |
Molecular Formula | C22H17ClN6O |
CAS# | 1201438-56-3 |
Inchi | InChI=1S/C22H17ClN6O/c1-13(28-21-19-20(25-11-24-19)26-12-27-21)17-10-14-6-5-9-16(23)18(14)22(30)29(17)15-7-3-2-4-8-15/h2-13H,1H3,(H2,24,25,26,27,28)/t13-/m0/s1 |
Inchi Key | SJVQHLPISAIATJ-ZDUSSCGKSA-N |
SMILES | CC(C1=CC2=C(C(=CC=C2)Cl)C(=O)N1C3=CC=CC=C3)NC4=NC=NC5=C4NC=N5 |
Size | 1g |
Supplier Page | http://www.selleckchem.com/products/ipi-145-ink1197.html |
Additional Information | https://file.selleck.cn/downloads/struct/IPI-145-INK1197-chemical-structure-s7028.gif |