GDC-0152
GDC-0152 is a potent antagonist of XIAP-BIR3, ML-IAP-BIR3, cIAP1-BIR3 and cIAP2-BIR3 with Ki of 28 nM, 14 nM, 17 nM and 43 nM in cell-free assays, respectively; less affinity shown to cIAP1-BIR2 and cIAP2-BIR2. Phase 1.
| Trivial name | N/A |
| Catalog Number | S7010 |
| Molecular Formula | C25H34N6O3S |
| CAS# | 873652-48-3 |
| Inchi | InChI=1S/C25H34N6O3S/c1-16(26-2)22(32)27-21(18-12-7-4-8-13-18)25(34)31-15-9-14-19(31)23(33)28-24-20(29-30-35-24)17-10-5-3-6-11-17/h3,5-6,10-11,16,18-19,21,26H,4,7-9,12-15H2,1-2H3,(H,27,32)(H,28,33)/t1 6-,19-,21-/m0/s1 |
| Inchi Key | WZRFLSDVFPIXOV-LRQRDZAKSA-N |
| SMILES | CC(C(=O)NC(C1CCCCC1)C(=O)N2CCCC2C(=O)NC3=C(N=NS3)C4=CC=CC=C4)NC |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/gdc-0152.html |
| Additional Information | https://file.selleck.cn/downloads/struct/GDC-0152-chemical-structure-s7010.gif |