Solcitinib
Solcitinib (GLPG0778, GSK2586184) is an inhibitor of JAK1 with an IC50 of 8-9 nM, and shows 11-, 55- and 23-fold selectivity over JAK2, JAK3 and TYK2, respectively.
| Trivial name | GLPG0778, GSK2586184 |
| Catalog Number | S5917 |
| Molecular Formula | C22H23N5O2 |
| CAS# | 1206163-45-2 |
| Inchi | InChI=1S/C22H23N5O2/c1-22(2)12-26(13-22)20(29)16-10-6-14(7-11-16)17-4-3-5-18-23-21(25-27(17)18)24-19(28)15-8-9-15/h3-7,10-11,15H,8-9,12-13H2,1-2H3,(H,24,25,28) |
| Inchi Key | MPYACSQFXVMWNO-UHFFFAOYSA-N |
| SMILES | CC1(CN(C1)C(=O)C2=CC=C(C=C2)C3=CC=CC4=NC(=NN43)NC(=O)C5CC5)C |
| Size | 10mM/1mL |
| Supplier Page | http://www.selleckchem.com/products/solcitinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/solcitinib-chemical-structure-s5917.gif |