Ruxolitinib Phosphate

Ruxolitinib Phosphate (INCB018424, INC424) is the phosphate salt form of Ruxolitinib. Ruxolitinib is the first potent, selective, JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays, >130-fold selectivity for JAK1/2 versus JAK3. Ruxolitinib kills tumor cells through toxic mitophagy. Ruxolitinib induces autophagy and enhances apoptosis.

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Trivial name	INCB018424, INC424
Catalog Number	S5243
Molecular Formula	C17H18N6.H3O4P
CAS#	1092939-17-7
Inchi	InChI=1S/C17H18N6.H3O4P/c18-7-5-15(12-3-1-2-4-12)23-10-13(9-22-23)16-14-6-8-19-17(14)21-11-20-16;1-5(2,3)4/h6,8-12,15H,1-5H2,(H,19,20,21);(H3,1,2,3,4)/t15-;/m1./s1
Inchi Key	JFMWPOCYMYGEDM-XFULWGLBSA-N
SMILES	C1CCC(C1)C(CC#N)N2C=C(C=N2)C3=C4C=CNC4=NC=N3.OP(=O)(O)O
Size	1g
Supplier Page	http://www.selleckchem.com/products/ruxolitinib-phosphate.html
Additional Information	https://file.selleck.cn/downloads/struct/ruxolitinib-phosphate-chemical-structure-s5243.gif