Hyaluronidase (Hyaluronate 4-glycanohydrolase, Hyaluronoglucosaminidase, Amphadase, Hydase, Vitrase) is a naturally occurring enzyme that degrades hyaluronic acid, which constitutes an essential part of the extracellular matrix. It depolymerizes hyaluronic acid by cleavage of glycosidic bonds and has been utilized in ophthalmic surgery.