Niclosamide
Niclosamide can inhibit DNA replication and inhibit STAT3 with IC50 of 0.7 μM in a cell-free assay. Niclosamide selectively inhibited the phosphorylation of STAT3 and had no obvious inhibition against the activation of other homologues (e.g., STAT1 and STAT5).
| Trivial name | BAY2353, Niclocide, NSC 178296 |
| Catalog Number | S3030 |
| Molecular Formula | C13H8Cl2N2O4 |
| CAS# | 50-65-7 |
| Inchi | InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19) |
| Inchi Key | RJMUSRYZPJIFPJ-UHFFFAOYSA-N |
| SMILES | C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/niclosamide-niclocide.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Niclosamide-chemical-structure-s3030.gif |