Tofacitinib
Tofacitinib is a novel inhibitor of JAK3 with IC50 of 1 nM in cell-free assays, 20- to 100-fold less potent against JAK2 and JAK1. Tofacitinib inhibits the expression of antiapoptotic BCL-A1 and BCL-XL in human plasmacytoid dendritic cells (PDC) and induced PDC apoptosis.
| Trivial name | CP-690550, Tasocitinib |
| Catalog Number | S2789 |
| Molecular Formula | C16H20N6O |
| CAS# | 477600-75-2 |
| Inchi | InChI=1S/C16H20N6O/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20)/t11-,13+/m1/s1 |
| Inchi Key | UJLAWZDWDVHWOW-YPMHNXCESA-N |
| SMILES | CC1CCN(CC1N(C)C2=NC=NC3=C2C=CN3)C(=O)CC#N |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/tofacitinib-cp-690550.html |
| Additional Information | https://file.selleck.cn/downloads/struct/CP-690550-chemical-structure-s2789.gif |