Gambogic Acid
Gambogic Acid (Guttatic Acid, Guttic Acid, Beta-Guttiferrin) activates caspases with EC50 of 0.78-1.64 μM and competitively inhibits Bcl-XL, Bcl-2, Bcl-W, Bcl-B, Bfl-1 and Mcl-1 with IC50 of 1.47, 1.21, 2.02, 0.66, 1.06 and 0.79 μM, respectively.
| Trivial name | Guttatic Acid, Guttic Acid, Beta-Guttiferrin |
| Catalog Number | S2448 |
| Molecular Formula | C38H44O8 |
| CAS# | 2752-65-0 |
| Inchi | InChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12, 15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23-,27+,36-,37+,38-/m1/s1 |
| Inchi Key | GEZHEQNLKAOMCA-RRZNCOCZSA-N |
| SMILES | CC(=CCCC1(C=CC2=C(C3=C(C(=C2O1)CC=C(C)C)OC45C6CC(C=C4C3=O)C(=O)C5(OC6(C)C)CC=C(C)C(=O)O)O)C)C |
| Size | 1g |
| Supplier Page | http://www.selleckchem.com/products/gambogic-acid.html |
| Additional Information | https://file.selleck.cn/downloads/struct/Gambogic-acid-chemical-structure-s2448.jpg |