Gefitinib-based PROTAC 3

Gefitinib-based PROTAC 3 which conjugates an EGFR binding element to a VHL ligand via a linker induces degradation of EGFR and mutants with DC50 of 11.7 nM and 22.3 nM in HCC827(Exon 19 del) and H3255 (L858R) cells, respectively.

Price Not Available 100mg Gefitinib-based PROTAC 3 Supplier Page

Trivial name	N/A
Catalog Number	S0070
Molecular Formula	C47H57ClFN7O8S
CAS#	2230821-27-7
SMILES	CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCOCCOCCCCCOC4=C(C=C5C(=C4)C(=NC=N5)NC6=CC(=C(C=C6)F)Cl)OC)O
Size	100mg
Supplier Page	http://www.selleckchem.com/products/gefitinib-based-protac-3.html
Additional Information	https://file.selleck.cn/downloads/struct/s0070-gefitinib-based-protac-3-chemical-structure.gif