KT 474

KT-474 (SAR444656) is a selective small-molecule degrader of IRAK4 in development for the treatment of TLR/IL-1R–driven autoimmune diseases. KT-474 potently downregulates R848 (TLR7/8) and lipopolysaccharide (LPS)-induced IL-6 and IL-8 production in peripheral blood mononuclear cells (PBMCs).

Price Not Available 1mg KT 474 Supplier Page

Trivial name	SAR-444656
Catalog Number	E1655
Molecular Formula	C44H49F2N11O6
CAS#	2432994-31-3
Size	1mg
Supplier Page	http://www.selleckchem.com/products/kt-474.html
Additional Information	https://file.selleck.cn/downloads/struct/e1655-KT-474-chemical-structure.png