SIRT7 inhibitor 97491
SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.
Catalog Number | E1150 |
Molecular Formula | C15H12ClN3O |
CAS# | 1807758-81-1 |
SMILES | NC1=CC=CC(=C1)NC2=NC=C(O2)C3=CC=C(Cl)C=C3 |
Size | 100mg |
Supplier Page | http://www.selleckchem.com/products/sirt7-inhibitor-97491.html |
Additional Information | https://file.selleck.cn/downloads/struct/e1150-sirt7-inhibitor-97491-chemical-structure.gif |