O-Demethyl-Gefitinib
O-Desmethyl gefitinib, a major active metabolite of gefitinib, is a potent EGFR (ErbB1/HER1) inhibitor, inhibits subcellular EGFR tyrosine kinase through a mechanism similar to that of gefitinib with IC50 values of 36 and 22 nM, respectively.
| Catalog Number | E0833 |
| Molecular Formula | C21H22ClFN4O3 |
| CAS# | 847949-49-9 |
| SMILES | OC1=CC2=C(C=C1OCCCN3CCOCC3)C(=NC=N2)NC4=CC(=C(F)C=C4)Cl |
| Size | 5mg |
| Supplier Page | http://www.selleckchem.com/products/o-demethyl-gefitinib.html |
| Additional Information | https://file.selleck.cn/downloads/struct/e0833-o-demethyl-gefitinib-chemical-structure.gif |