Pristane (Norphytane) is a naturally occurring hydrocarbon oil found in small quantities in many plants, in various marine organisms, and as the most active component of mineral oil. Pristane is a non-antigenic adjuvant, and induces MHC class II-restricted, arthritogenic T cells in the rat[2].In Vitro: Pristane activates CD4+ αβT cells that are MHC class II restricted and arthritogenic.In Vivo: Pristane activates CD4+ alpha beta T cells that are MHC class II restricted and arthritogenic in vivo[2].