SGK1-IN-1 is a highly active and selective inhibitor of SGK-1, with an IC50 of 1 nM.IC50 & Target: IC50: 1 nM (SGK-1)[2].In Vitro: SGK1-IN-1 (14n) shows an acceptable SGK isoform selectivity with a good activity on hSGK2 and a moderate activity on the hSGK3, with IC50s of 1, 41 nM at 10 μM and 50 μM ATP concentration, respectively. SGK1-IN-1 also displays cellular activity in a SGK1-dependent phosphorylation of GSK3β assay in U2OS cells with activities of 0.69 μM[2].