VU0650786| ChemScene
VU0650786 is a potent and selective CNS penetrant negative allosteric modulator of metabotropic glutamate receptor subtype 3 (mGlu3 NAM), with an IC50 of 392 nM. VU0650786 has antidepressant and anxiolytic activity in rodents.IC50 & Target: IC50: 392 nM (mGlu3).In Vivo: VU0650786 (VU786) (i.p., 30 mg/kg) increases the proportion of c-Fos-positive cells by approximately 4-fold, enhances synaptic strength in cone cell subpopulations, weakens thalamocortical long-term depression (LTD), and reduces passive coping in acute models of antidepressant-like activity in inducible cFos-EGFP mice[2].
The pharmacokinetic parameters of VU0650786 (compound 106) in rats.
| Parameters | IV (0.2 mg/kg) |
| t1/2 (min) | 42 |
| CL plasma (mL/min/kg) | 37 |
| VSS (L/kg) | 1.6 |
| Trivial name | VU0650786 |
| Catalog Number | CS-0030141 |
| Molecular Formula | 387.80 |
| CAS# | 1809085-30-0 |
| Purity | >98% |
| Condensed Formula | C18H15ClFN5O2 |
| Size | 25mg |
| Supplier Page | www.chemscene.com/1809085-30-0.html |