RU-301 is a pan TAM inhibitor that blocks Gas6-induced TAM activation and tumorigenicity. RU-301 significantly reduces nonalcoholic steatohepatitis (NASH) fibrosis, along with attenuates ERK activation and TGFβ1 expression. RU-301 can be used in studies of cancer and nonalcoholic steatohepatitis[2].In Vitro:RU-301 (10 μM; 30 min) inhibits native TAMs activation in H1299 cells.
RU-301 (10 μM; 24 h) inhibits migration of H1299 and MDA-MB-231 cells.
RU-301 (10 μM; 14 days) inhibits growth of H1299 clonogenic cells under Gas6.In Vivo:RU-301 (100, 300 mg/kg; i.p.; single daily for 4 days) inhibits tumor growth in lung cancer xenograft model.
RU-301 (300 mg/kg; i.p.; 3 times a week for 4 weeks) reduces liver fibrosis in mice[2].