Tricetin is a potent competitive inhibitor of the Keap1-Nrf2 Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson’s disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway.In Vitro: Tricetin is mainly found in natural plants such as?Ginkgo biloba?L.,?Carica papaya?L. and?Murraya exotica?L.?Tricetin activates the Nrf2/HO-1 pathway to protect cells from oxidative stress. Tricetin possessed the protective effect on dopamine neurons of?C. elegans. Tricetin has?cytostatic?properties and anti-metastatic activity of various?solid tumors.
Pretreatment?with Tricetin (20, 40, and 80 μM; for 4 hours) significantly improves 6-OHDA (200?μM)-induced SH-SY5Y cells viability and suppresses mitochondria-mediated apoptosis.
Tricetin (80?μM; for 1, 2 and 4?h) markedly decreased the expressions of p-JNK and p-p38.