TMX-4113 is a degrader of phosphodiesterase 6D (PDE6D) and casein kinase 1α (CK1α). TMX-4113 can be used for the research of cancer.In Vitro: TMX-4113 (compound 21; 1 μM; 4 h) shows a high degradation preference for PDE6D and CK1α in MOLT4 cells.
TMX-4113 (0 nM, 40 nM, 200 nM, 1μM; 4h) induces degradation of PDE6D in MOLT4 cells.
TMX-4113 (0 nM, 40 nM, 200 nM, 1μM; 4h) degrades over 50% of CK1α at a dose of 40 nM in MM.1S cells.