Sucunamostat (hydrochloride)| ChemScene
Sucunamostat (SCO-792) hydrochloride is an orally active and reversible enteropeptidase inhibitor with IC50s of 4.6 nM and 5.4 nM for rat enteropeptidase and human enteropeptidase, respectively. Sucunamostat hydrochloride can slowly dissociate from enteropeptidase in vitro and inhibit protein digestion in vivo.IC50 & Target:IC50: 4.6 nM (rat enteropeptidase), 5.4 nM (human enteropeptidase)In Vivo:Sucunamostat hydrochloride (10 and 30 mg/kg; PO, single dosage) effectively and dose-dependently inhibits plasma branched-chain amino acids (BCAA) elevations induced by oral protein dosing in rats.
Pharmacokinetic Parameters of Sucunamostat hydrochloride in male Sprague-Dawley rats
| PO (10 mg/kg) | IV (2 mg/kg) | |
| Cmax (ng/mL) | 6.60 ± 1.36 | 564 ± 58 |
| Tmax (h) | 1.7 ± 0.6 | |
| AUC0-24 (ng/mL·h) | 54.1 ± 7.5 | 303 ± 23 |
| AUCinf (ng/mL·h) | 49.8 ± 5.4 | 304 ± 30 |
| VdSS (mL/kg) | 1290 ± 299 | |
| CLp (mL/min/kg) | 663 ± 66 | |
| bioavailability (%) | 0.4 |
| Trivial name | Sucunamostat (hydrochloride) |
| Catalog Number | CS-0616930 |
| Alternative Name(s) | SCO-792 (hydrochloride) |
| Molecular Formula | 506.89 |
| Purity | >98% |
| Condensed Formula | C22H23ClN4O8 |
| Size | 10mg |
| Supplier Page | www.chemscene.com/CS-0616930.html |