SIS3 (free base)| ChemScene
SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2.IC50 & Target:Smad3, ALK-5In Vitro: SIS3 free base attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4.
| Trivial name | SIS3 (free base) |
| Catalog Number | CS-0019029 |
| Molecular Formula | 453.53 |
| CAS# | 521985-36-4 |
| Purity | >98% |
| Condensed Formula | C28H27N3O3 |
| Size | 50mg |
| Supplier Page | www.chemscene.com/521985-36-4.html |