PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1).IC50 & Target: IC50: 812 nM (RH4); 3200 nM (RH30); 1895 nM (OSA-CL); 1113 nM (TC-32)In Vitro: PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively.
PFI-90 (3 μΜ; 24 hours) increases apoptosis in RH4 and SCMC cells.