Tunicamycin V (Tunicamycin A) is a nucleoside natural product that inhibits bacterial phospho-N-acetylmuramyl-pentapeptide transferase (MraY) with an IC50 of 0.35?μM. Tunicamycin V has antibacterial activties[2].IC50 & Target:IC50: 0.35 μM (phospho-N-acetylmuramyl-pentapeptide transferase (MraY))In Vitro: Tunicamycins are nucleoside natural products isolated from the fermentation broths of Streptomyces lysosuperficus in 1971 and exhibit a variety of biological properties including antibacterial, antiviral, antifungal, and antitumor activities. Tunicamycins strongly inhibit UDP-N-acetylglucosamine (GlcNAc): polyprenol phosphate translocase, the enzyme responsible for the first N-acetylglucosamination of the N-linked glycopeptide in endothelial reticulum (ER)[2].