(Rac)-Modipafant| ChemScene

(Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection[2].In Vivo: (Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection.
(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC50=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively).
(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia.

Trivial name (Rac)-Modipafant
Catalog Number CS-0031421
Alternative Name(s) UK-74505
Molecular Formula 605.09
CAS# 122956-68-7
Purity >98%
Condensed Formula C34H29ClN6O3
Size 10mg
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