(Rac)-Modipafant| ChemScene
(Rac)-Modipafant (UK-74505) is an orally active, selective, long-acting irreversible platelet activating factor receptor (PAFR) antagonist. (Rac)-Modipafant prevents dengue infection[2].In Vivo: (Rac)-Modipafant (UK-74505) (10 mg/kg; p.o.; twice a day until day 10) prevents Severe Dengue Infection.
(Rac)-Modipafant exhibits highly selective, time-dependent inhibition of PAF-induced aggregation of rabbit washed platelets (IC50=26.3 and 1.12 nM after 0.25 and 60 min preincubation, respectively).
(Rac)-Modipafant (5-20 mg/kg; p.o.) dose-dependently inhibits the Zymosan -induced articular hyperalgesia.
Trivial name | (Rac)-Modipafant |
Catalog Number | CS-0031421 |
Alternative Name(s) | UK-74505 |
Molecular Formula | 605.09 |
CAS# | 122956-68-7 |
Purity | >98% |
Condensed Formula | C34H29ClN6O3 |
Size | 10mg |
Supplier Page | www.chemscene.com/122956-68-7.html |