STM2457 is a first-in-class, highly potent, selective and orally active METTL3 inhibitor with an IC50 of 16.9 nM. STM2457 can be used for the research of acute myeloid leukaemia (AML)[2].In Vitro: STM2457 (Compound 72) inhibits MOLM13 cells proliferation with an IC50 of 8.699 μM.