NXP800| ChemScene
NXP800 (CCT361814) is a potent and orally active heat shock factor 1 (HSF1) pathway inhibitor. NXP800 has?the?potential?for?cancer research[2].In Vitro:NXP800 (example 169) inhibits U20S cells viability (IC50=0.056 μM).
In Vivo:NXP800 (35 mg/kg; po; once daily for 20 days) inhibits the established SK-OV-3 human ovarian cancer solid tumor xenografts grown subcutaneously, with tumor growth inhibition (TGI) of 120% relative to control[2].
Pharmacokinetic Analysis[2]
| Species | Route | Dose (mg/kg) | Tmax (h) | AUClast (ng·h/mL) | Cltb (mL/min/kg) | t1/2 (h) | F (%) | AUCu0-t (h·nM) | Free Cav0-24h (nM) | Clu (mL/min/kg) |
| mouse | po/iv | 5/5 | 2.0 | 6000 (7800-4600) (po) | 10 (10-9.7) (iv) | 4.0 | 42 (po) | 72 | 3.3 | 830 (iv) |
| rat | po/iv | 5/1 | 6.0 | 2600 (po) | 24 (iv) | 3.1 | 45 (po) | 86 | 3.7 | 730 (iv) |
| dog | po/iv | 2.5/0.5 | 2.0 | 250 (po) | 21 (iv) | 1.4 | 9.1 (po) | 35 | 1.9 | 150 (iv) |
| Trivial name | NXP800 |
| Catalog Number | CS-0435291 |
| Alternative Name(s) | CCT361814 |
| Molecular Formula | 569.63 |
| CAS# | 1693734-80-3 |
| Purity | >98% |
| Condensed Formula | C32H32FN5O4 |
| Size | 5mg |
| Supplier Page | www.chemscene.com/1693734-80-3.html |