ThioLox is a competitive 15-lipoxygenase-1 (15-LOX-1) inhibitor with a Ki of 3.30 μM. ThioLox shows anti-inflammatory and neuroprotective properties.IC50 & Target:Ki: 3.30 μM (15-LOX-1)In Vitro:ThioLox shows competitive inhibition thus indicating non-covalent interaction with the active site of the 15-LOX-1.
ThioLox (50 μM; 24 h) inhibits interleukin (IL-1β, IL-6, IL-8, IL-12b, TNFα and iNOS) expression in precision-cut lung slices (PCLS).
ThioLox (10 μM; 16 h) prevent lipid peroxidation and mitochondrial superoxide formation in neuronal cells.
ThioLox (5-20 μM; 14-16 h) protects HT-22 cells against glutamate toxicity and significantly reduces neuronal cell death.In Vivo:ThioLox has a logP of 3 and shows values that comply very well with the BBB permeability.