Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 has the potential for the neuropathic pain.IC50 & Target: IC50: 1.54μM (hERG).
Ki : 1.14 nM (Sigma-1 receptor); 1239 nM (Sigma-2 receptor)