SB-431542
A potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM). It inhibits ALK4 only at higher concentrations (IC50 = 140 nM). Suppresses renewal in embryonic and induced pluripotent stem (iPS) cells and promotes their differentiation through its effect on Smad signaling pathway.
| Catalog Number | ABS-061 |
| Alternative Name(s) | 4-[4-(1,3-benzodioxol-5-yl)-5-pyridin-2-yl-1H-imidazol-2-yl]benzamide |
| CAS# | 301836-41-9 |
| Inchi | InChI=1S/C22H16N4O3/c23-21(27)13-4-6-14(7-5-13)22-25-19(20(26-22)16-3-1-2-10-24-16)15-8-9-17-18(11-15)29-12-28-17/h1-11H,12H2,(H2,23,27)(H,25,26) |
| Inchi Key | FHYUGAJXYORMHI-UHFFFAOYSA-N |
| SMILES | C1OC2=C(O1)C=C(C=C2)C3=C(NC(=N3)C4=CC=C(C=C4)C(=O)N)C5=CC=CC=N5 |
| Size | Inquiry |
| Supplier Page | https://www.agingclocks.com/sb-431542-item-1525.html |