Splitomicin
Potent inhibitor of yeast NAD⁺-dependent histone deacetylase Sir2p (IC50 = 60 µM). Sensitizes mammalian cells to a variety of DNA-damaging agents by abrogating Sir2p activity on p53. Acts by either altering or blocking access to the acetylated histone binding pocket.
| Catalog Number | ABH-026 |
| Alternative Name(s) | 1,2-Dihydro-3H-naphtho[2,1-b]pyran-3-one |
| CAS# | 5690-03-9 |
| Inchi | InChI=1S/C13H10O2/c14-13-8-6-11-10-4-2-1-3-9(10)5-7-12(11)15-13/h1-5,7H,6,8H2 |
| Inchi Key | ISFPDBUKMJDAJH-UHFFFAOYSA-N |
| SMILES | C1CC(=O)OC2=C1C3=CC=CC=C3C=C2 |
| Size | Inquiry |
| Supplier Page | https://www.agingclocks.com/splitomicin-item-1441.html |