YNT-185 dihydrochloride

Potent and selective orexin OX2 receptor agonist (EC50 = 28 nM at human OX2 expressed in CHO cells). Displays approximately 100-fold selectivity for OX2 over OX1 (EC50 = 2.75 μM at human OX1 expressed in CHO cells). Depolarizes OX2-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.

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Catalog Number	T37112
Molecular Formula	C33H39Cl2N5O5S
CAS#	1804978-82-2
SMILES	Cl.Cl.COc1ccc(cc1S(=O)(=O)Nc1cccc(NCCNC(=O)c2ccccc2N(C)C)c1)-c1cccc(c1)C(=O)N(C)C
Size	1 mg
Supplier Page	https://www.targetmol.com/compound/ynt_185
Additional Information	https://www.targetmol.com/datasheet/T37112