AKB-6899
AKB-6899 is an inhibitor of prolyl hydroxylase domain 3 (PHD3) and increases the soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages. AKB-6899 leads to stabilization of HIF-2α which induces sVEGFR-1 production from tumor-associated macrophages and decreases tumor growth.
| Catalog Number | T29797 |
| Alternative Name(s) | AKB6899 |
| Research Area | Tyrosine Kinase/Adaptors|||Angiogenesis|||Metabolism|||Chromatin/Epigenetic |
| Molecular Formula | C14H11FN2O4 |
| CAS# | 1007377-55-0 |
| Purity | 97.11% |
| SMILES | OC(CNC(c(c(O)c1)ncc1-c1cccc(F)c1)=O)=O |
| Size | 50 mg |
| Supplier Page | https://www.targetmol.com/compound/AKB-6899 |
| Additional Information | https://www.targetmol.com/datasheet/T29797 |