AMG 511
AMG 511 is a potent and orally available pan inhibitor of class I PI3Ks(Kis of 4 nM, 6 nM, 2 nM and 1 nM for PI3Kα, β, δ and γ, respectively). It exhibits anti-tumor activity in mouse glioblastoma xenograft model[1]. AMG 511 significantly suppresses PI3K signaling that is indicated by p-Akt (Ser473) decrease.
| Catalog Number | T14214 |
| Research Area | PI3K/Akt/mTOR signaling |
| Molecular Formula | C22H28FN9O3S |
| CAS# | 1253573-53-3 |
| SMILES | C[C@H](c(cc1-c2nc(N)nc(C)n2)cnc1Nc(cc1F)cnc1OC)N(CC1)CCN1S(C)(=O)=O |
| Size | 10 mg |
| Supplier Page | https://www.targetmol.com/compound/AMG 511 |
| Additional Information | https://www.targetmol.com/datasheet/T14214 |