AMD 3465
AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM). However, it has no effect on CCR5-using (R5) viruses. AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells.
| Catalog Number | T14208 |
| Alternative Name(s) | GENZ-644494 |
| Research Area | Proteases/Proteasome|||Microbiology/Virology |
| Molecular Formula | C24H38N6 |
| CAS# | 185991-24-6 |
| SMILES | N=1C=CC=CC1CNCC2=CC=C(C=C2)CN3CCNCCCNCCNCCC3 |
| Size | 5 mg |
| Supplier Page | https://www.targetmol.com/compound/AMD 3465 |
| Additional Information | https://www.targetmol.com/datasheet/T14208 |