(20S)-21-(Acetyloxy)-20-hydroxy-18-iodo-pregn-4-en-3-one is an intermediate used in the synthesis of 11-Deoxy-18-hydroxycorticosterone (D239680), which is an analog of Corticosterone (C695700); a glucocorticoid and intermediate in the biosynthesis of Aldosterone (A514700) which is an adrenocortical steroid isolated from the adrenal cortex.