JohnPhos, a bulky phosphine ligand, was employed as catalyst in the following studies: Hydrophenoxylation of unactivated internal alkynes; Microwave-mediated Suzuki-Miyaura cross-coupling of benzylic bromides; Pharmaceutical synthesis of novel imidazo[1,2-a]pyridines, having potent activity against the herpes virus.; Barluenga’s coupling of vinyl bromides with hydrazines; Pd-catalyzed 2,3-diarylation of α,α-disubstituted-3-thiophenemethanols, via cleavage of C-H and C-C bonds. Ligand utilized in amination of aryl halides and aryl triflates.Catalyst for: Decarboxylative cross-coupling of dialkoxybenzoic acids with diaryl disulfides or diaryl diselenides; Stereoselective preparation of imidazolidinones via intramolecular hydroamination of N-allylic-N-arylureas; Regioselective arylation of olefins with aryl chlorides; Cross-coupling reaction for the synthesis of polyunsaturated macrolactones; Regioselective O-alkylation reactions; Sonogashira-type cross coupling.