(+)-ZK 216348
(+)-ZK 216348 is a selective nonsteroidal glucocorticoid receptor (GR) agonist for the treatment of experimental colitis (IC50 values of 20, 20, and 80 nM for GR, Progesterone (PR) and Mineralocorticoid (MR) receptors, respectively). (+)-ZK 216348 exhibits antiinflammatory activity for both systemic and topical application, and shows no negative effects on intestinal epithelial migration or proliferation.
| Catalog Number | 669073-68-1 |
| Alternative Name(s) | ZK216348; ZK 216348; ZK-216348; 4-(2,3-dihydro-1-benzofuran-7-yl)-2-hydroxy-4-methyl-N-(4-methyl-1-oxo-2,3-benzoxazin-6-yl)-2-(trifluoromethyl)pentanamide |
| Molecular Formula | C24H23F3N2O5 |
| CAS# | 669073-68-1 |
| Purity | 99% |
| Inchi | InChI=1S/C24H23F3N2O5/c1-13-17-11-15(7-8-16(17)20(30)34-29-13)28-21(31)23(32,24(25,26)27)12-22(2,3)18-6-4-5-14-9-10-33-19(14)18/h4-8,11,32H,9-10,12H2,1-3H3,(H,28,31) |
| Inchi Key | VRZVKIJRJRBQJT-UHFFFAOYSA-N |
| Size | Please inquire |
| Supplier Page | https://www.bocsci.com/zk-216348-cas-669073-68-1-item-54894.html |