(±)-HIP-A

(±)-HIP-A is a potent and non-competitive excitatory amino acid transporter (EAAT) blocker. (±)-HIP-A displays no affinity for NMDA and metabotropic glutamate receptors, and weak affinity for AMPA and kainate receptors (IC50 = 43 and 8 μM, respectively). (±)-HIP-A inhibits glutamate-induced [3H]D-aspartate release (IC50 = 1.6 μM) rather than [3H]L-glutamate uptake (IC50 = 18 μM).

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Catalog Number 227619-64-9
Alternative Name(s) (±)-3-Hydroxy-4,5,6,6a-tetrahydro-3aH-pyrrolo[3,4-d]isoxazole-4-carboxylic acid
Molecular Formula C6H8N2O4
CAS# 227619-64-9
Purity ≥98%
Inchi InChI=1S/C6H8N2O4/c9-5-3-2(12-8-5)1-7-4(3)6(10)11/h2-4,7H,1H2,(H,8,9)(H,10,11)
Inchi Key XJSXFNHFIBCTDU-UHFFFAOYSA-N
Size Please inquire
Supplier Page https://www.bocsci.com/hip-a-cas-227619-64-9-item-103042.html