Reactant for preparation of:• Highly substituted acenes via rhodium-catalyzed oxidative coupling with alkynes• Anticancer pyrimidines with multiple-kinase inhibitory effect• 3,4-ring fused 7-azaindoles and deazapurines as potent JAK2 inhibitors• Polycyclic azaindoles as JAK2 inhibitors• ROS1 receptor tyrosine kinase inhibitors• 2-aminopyrazolopyridines as Polo-like kinase 1 inhibitors